Cannabidiol is a phytocannabinoid discovered in 1940. It is one of 113 identified cannabinoids in cannabis plants, along with tetrahydrocannabinol, and accounts for up to 40% of the plant’s extract. Reference: Wikipedia
Drug class: Cannabinoid
Elimination half-life: 18–32 hours
Other names: CBD, cannabidiol, (−)-cannabidiol
Solubility in water: insoluble
Melting point: 66 °C (151 °F)
Bioavailability: • Oral: 13–19%; • Inhaled: 31% (11–45%)
Cannabichromene (CBC), also called cannabichrome, cannabichromene, pentyl cannabichromene, or cannabichromene,is one of the hundreds of cannabinoids found in the Cannabis plant, and is, therefore, a phytocannabinoid. It bears structural similarities to the other natural cannabinoids, including tetrahydrocannabinol (THC), tetrahydrocannabivarin (THCV), cannabidiol (CBD), and cannabinol (CBN), among others. CBC and its derivatives are as abundant as cannabinol in cannabis.It is not scheduled by the Convention on Psychotropic Substances. It is more common in tropical cannabis varieties. Reference: https://en.wikipedia.org/wiki/Cannabichromene
Cannabidiolic acid (CBDA), is a cannabinoid found in cannabis plants.It is most abundant in the glandular trichomes on the female seedless flowers or more accurately infructescence often colloquially referred to as buds. CBDA is the chemical precursor to cannabidiol (CBD). Through the process of decarboxylation, cannabidiol is derived via a loss of carbon and two oxygen atoms from the 1 position of the benzoic acid ring. Reference:
Cannabidivarin (CBDV) is a non-psychoactive cannabinoid found in Cannabis. It is a homolog of cannabidiol (CBD), with the side chain shortened by two methylene bridges (CH2 units). Although cannabidivarin (CBDV) is usually a minor constituent of the cannabinoid profile, enhanced levels of CBDV have been reported in feral populations of C. indica ( = C. sativa ssp. indica var. kafiristanica) from northwest India, and in hashish from Nepal.
CBDV has anticonvulsant effects.It was identified for the first time in 1969 by Vollmer et al.
Similarly to CBD, it has seven double-bond isomers and 30 stereoisomers (see: Cannabidiol#Double bond isomers and their stereoisomers). It is not scheduled by the Convention on Psychotropic Substances. It is being actively developed by GW Pharmaceuticals (as GWP42006) because of a demonstrated neurochemical pathway for previously observed anti-epileptic and anticonvulsant action. GW has begun a phase 2 trial for adult epilepsy, and is to begin trials of this CBDV product in children in 2016 in Australia.
Cannabigerol (CBG) is one of more than 120 identified cannabinoid compounds found in the plant genus Cannabis. Cannabigerol is the decarboxylated form of cannabigerol acid, the parent molecule from which other cannabinoids are synthesized. Cannabigerol is a minor constituent of cannabis. During plant growth, most of the cannabigerol is converted into other cannabinoids, primarily tetrahydrocannabinol (THC) or cannabidiol (CBD), leaving about 1% cannabigerol in the plant. Reference: https://en.wikipedia.org/wiki/Cannabigerol
Cannabinol (CBN) is a mildly psychoactive cannabinoid found in trace amounts of Cannabis. CBN is mostly found in cannabis that is aged and stored and is derived from the plant’s main psychoactive chemical, tetrahydrocannabinol (THC).
It was the first cannabis compound to be isolated from a cannabis extract in the late 1800s. Then by the 1930s, the first to have its structure determined, and in 1940, to have scientists achieved its chemical synthesis.
Formation: There is usually little CBN in a fresh plant. However, if cannabis is exposed to air or ultraviolet light (for example, in sunlight) for a prolonged period of time, THCA will convert to cannabinolic acid (CBNA). CBN is then formed by the decarboxylation of CBNA.[cit
Pharmacology: CBN acts as a partial agonist at the CB1 receptors, but has a higher affinity to CB2receptors; however, it has lower affinities relative to THC.
Chemistry: In contrast to THC, CBN has no double-bond isomers or stereoisomers. Both THC and CBN activate the CB1 and CB2receptors.
Legal status: CBN is not listed in the schedules set out by the United Nations Single Convention on Narcotic Drugs from 1961 nor their Convention on Psychotropic Substances from 1971, so the signatory countries to these international drug control treaties are not required by these treaties to control CBN. As of 2021 in the United States, CBN and other cannabis extracts remain illegal under federal law to prescribe for medical use or to use as an ingredient in dietary supplements or other foods, and sales or possession of CBN could potentially be prosecuted under the Federal Analogue Act.In December 2016, the Drug Enforcement Administration added marijuana extracts, which are defined as any “extract containing one or more cannabinoids that have been derived from any plant of the genus Cannabis, other than the separated resin”, to Schedule I.
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